At the 1962 Savannah District Conference, it was recommended that a survey of Halcyon Bluff, Rio Vista, Kings Wood, and Cresthill be done because the Chatham County Chamber of Commerce predicted that this area would grow to 20,000 people by 1970. Rev. F. J. Beverly, Executive Secretary of the Conference Board of Church Extension, came to Savannah in the spring of 1964, to conduct a formal survey of the area and found that fifty families were definitely interested in a church and fifty-five families indicating a tentative interest. On May 13, 1964, an organizational meeting was held at Wesley Gardens with Larry Roberts, Thomas Johnson, George Herndon, Jean and Joe Nicholson, and Lewis Bazemore in attendance. The name St. Luke was chosen. These people did not wait for a minister to be assigned
but started holding services at Wesley Gardens with guest preachers. The first assigned pastor was Rev. J. Don Jordan. He arrived on June 18, 1964, and was installed in a temporary parsonage in a cottage at Wesley Gardens. The first Sunday school was held on June 12, 1964. In the summer of 1964, the congregation met in Hesse Elementary School, but the $35 fee that the Board of Education charged to use the school was too much and so meetings were moved to people's homes. The first MYF was formed on July 5, 1964, and both junior and senior groups were organized.
On August 15, 1964, the District Board of Missions, with the help from the Kingdom Builders Club and the South Georgia Conference, purchased the present location consisting of three acres of land with three houses on it. One of the homes was to be a parsonage. The other two were renovated to be used as a church and educational building. Extensive remodeling was done by the laymen led by Lewis Bazemore, Chairman of the Board of Trustees. On August 23, 1964, the church was officially charted with forty members, and on August 30, 1964, the first service was held in the new church. A building study committee was formed in early 1965, and a building committee was appointed and met on May 25, 1966. In 1967, Rev. Glen Brinson was appointed pastor and groundbreaking ceremonies were held on June 30, 1968. The plans included a fellowship hall, kitchen, nursery, two classrooms, church office, pastor's study, and restrooms. Construction began in January 1969.
The first meeting of the Woman's Society of Christian Service was held on August 19, 1964, at the home of Mrs. C. B. Harrell with eight members. In June 1970, Rev. Lonzie Wester served St. Luke, and in 1973 Rev. Reid Smith became Interim Pastor. In June 1974, Madison Morgan, a lay minister, was appointed, and in 1975 the parsonage was swapped for a larger, newer parsonage. In June 1978, Rev. Ted Bass was sent to St. Luke and a drive were launched to ask members to donate pews in memory or honor of loved ones
. This was successful and the sanctuary was refurnished, carpeted and painted.