Before the organization of this church on its present site, there was an organized church on Frederica Road meeting in a tabernacle built in the early 1930s and served by the pastor from Darien, Rev. Roy C. Sampley
. The location was away from the majority of the full-time residents, so it became a part of the community church near the present church site. Alfred Brockinton, who had belonged with his father, Captain Sammy, to the first organization, desired an active Methodist Church. Rev. A. A. Waite, Sr. and Rev. I. L. Bishop, pastors in Brunswick at the time, helped to organize this church in the home of Alfred Brockinton, November 19, 1938. There were 104 members. The church names have been Wesley, Memorial, St. Simons Methodist, Wesley Chapel and again St. Simons. It was placed on the Arco-Taylor's Charge with Rev. I. L. Bishop as pastor in 1938. The first building was of hollow tile with the Sunday school rooms added of the same tile in 1940 and 1947. The sanctuary was enlarged in 1950. In 1954, the parsonage was built. The Davis Thorpe social hall building was built in 1971, with memorial gifts from many other groups as Mr. Thorpe was the bus driver for all island high school students. The Woman’s Society of Christian Service was organized in 1943, by Mrs. I. L. Bishop. During 1980-1981, the church sponsored a Laotian refugee family. A four-day fundraising campaign, called A Big Step in Faith, for a new sanctuary was held and construction on the new building began. The former sanctuary was maintained as a chapel when the new sanctuary was opened in April 1981.
In 1966, the first Meadows Fried Chicken dinner, later a large fundraiser for Boy Scout Troop 248, was held by the choir to raise money for the pastor's study. In May 1982, a dedication service was held for memorial pews and stained glass windows in the new sanctuary. Members of the church helped to form a new island Methodist church, Wesley at Frederica,
which was constituted in April 1987. In 1988, a new Wicks pipe organ was installed in the sanctuary. For over twenty years the church organized the community-wide choral presentation of Handel's "Messiah" during the Christmas season. In 2005, the upper floor of the children's wing of the Strickland Building was renovated which included multiple painted wall murals. Also, in 2005, the church was instrumental in starting a new Methodist Church, the Chapel, in North Brunswick. During 2012, the church pre-school, located on the first floor of the Strickland Building, was upgraded to meet state requirements through extensive renovations and now includes full daycare. Through the years, the church has continued to support local and regional missions, including Operation Bed Spread, which provides beds and sheets for needy families, Vial of Life, Faith Works, a local organization who also works with the needy and homeless, and Magnolia Manor Auxiliary. The church celebrated its 75th anniversary in November 2013